Brain substance on MRI: are changes visible?

MRI: T1-weighted axial view. Red arrow (1) indicates the right hemisphere of the brain, (2) gray matter, (3) white matter

Brain changes on MRI can be caused by various reasons. Experts are confident that the earlier the disease is identified and treatment is started, the greater the chances of a successful outcome. Magnetic resonance imaging of the head vessels can be performed on most people without any serious side effects or long-term consequences. Modern contrast agents based on gadolinium chelates do not cause complications in 98% of cases. The only serious obstacle to the diagnostic procedure is the presence of metal in the human body, which requires another method of examination, for example, CT.

What brain pathologies does MRI show?

The distribution of white and gray matter and pathological processes within the brain are illustrated in detail by MRI. Magnetic scanning is one of the high-precision non-invasive methods of instrumental diagnostics for neurosurgeons, neurologists, and, less often, psychiatrists. Analysis of changes in the two main components of the brain - gray and white matter - is important for clinical diagnosis and therapy of a huge number of diseases: epilepsy and episyndrome, stroke, Alzheimer's disease, malignant and benign neoplasms, multiple sclerosis, infectious and inflammatory processes, post-traumatic injuries, etc.

Distribution of gray and white matter in the brain

Gray matter

The gray matter of the brain is responsible for most of the functions of higher nervous activity and is represented by neuron bodies, glial cells, a cluster of dendrites, thin tiny blood vessels - capillaries - and unmyelinated axons. The main histological structures are centers, each of which controls some action: the act of urination, defecation, heartbeat, etc. Neurosurgeons consider the gray color to be conventional; rather, this substance has an earthy tint. The composition of the main structures of the brain is clearly distinguishable, mainly due to differences in water and protein content. This allows one zone to be differentiated from another on tomograms. Pathological processes localized in the gray matter lead to disturbances in perception, speech, emotions, memory, sensory sensitivity, will, muscle movements, etc.

White matter

The white color is caused by bundles of nerve fibers covered with a myelin sheath. The main purpose of this brain structure is the transmission of impulses from the main centers to the periphery (lower links of the nervous system).

Preventive measures

Any disease is easier to prevent than to treat, and focal changes in the brain substance of a dyscirculatory nature are no exception. Every person in this world should try to lead an active lifestyle. Exercising significantly improves metabolism and cerebral circulation. So start exercising today.

Pay attention to what you eat and adjust your diet. Of course, it is very difficult to immediately switch to a healthy diet, especially if you are a big fan of unhealthy foods. So do it gradually, it will put much less stress on your body.

Learn not only to work, but also to relax. Constant stressful situations are fraught with consequences for your well-being and lead to the development of many dangerous diseases.

Also take care of your sleep. The optimal sleep time for an adult is seven to eight hours a day. Both lack of sleep and excess of it will negatively affect your health.

What brain diseases can MRI detect?

Changes in white matter on MRI in various pathologies

MRI of the brain is performed to diagnose:

• tumors. MRI is one of the highly informative methods in identifying oncological processes in the brain; it allows one to establish the relationship of the tumor with surrounding tissues;
• metastatic lesions (tumor screenings). For many malignant neoplasms, the brain is the target organ.
• lesions that appeared against the background of various angiopathy, hypertension, atherosclerosis, migraine, hyperhomocysteinemia;
• inflammatory processes, including those of an autoimmune nature: multiple sclerosis, sarcoidosis, etc.;
• infections: HIV, tuberculosis, herpes, neurosyphilis, mycoplasmosis, etc.;
• post-traumatic changes after receiving a direct blow to the head or to identify lesions after radiation therapy, which is also considered by radioradiologists as an altering factor;
• various metabolic disorders, toxic damage;
• heart attacks and strokes, foci of ischemia, dyscirculatory encephalopathy (impaired blood microcirculation is manifested by hypoxic/dystrophic changes in the brain);
• vascular malformations;
• anomalies and developmental defects.

What diseases cause lesions in the brain on MRI?

The principle of constructing an image during MRI of the brain is based on combining many slices, ranging in size from 1 mm, into a single whole, but the doctor can evaluate each layer separately

An example of damage to gray matter with the formation of foci is heterotopia and its most common variant is subependymal, which is associated with epilepsy and developmental delay. In the diagnosis of this pathology, magnetic resonance imaging of the brain is the predominant study. Epileptic seizures may appear in adulthood, which requires exclusion of a tumor. Changes in the gray matter are found in schizophrenia (loss of tissue density in the superior frontal lobule, left superior temporal gyrus), bipolar disorder, etc. Foci in the brain of a patient suffering from mental disorders are often found, but the main criterion for diagnosis is symptoms.

Differentiation of white matter pathologies includes a whole spectrum of diseases, but MRI of the brain also shows areas that do not always indicate disease and are a normal variant in older people. The latter are included in the concept of “benign aging of the brain.” Destructive zones can occur against the background of hypoxia and ischemia. On MRI, changes in the white matter of the brain associated with focal lesions are found in:

An MRI image shows changes in the white matter of the brain: green arrows indicate multiple demyelinated lesions in multiple sclerosis

• Multiple sclerosis. MS is an inflammatory (autoimmune) disease that causes spots in the white matter of the brain. The pathogenesis is not known for certain. Similar areas are found in herpesvirus infection, leukoencephalopathy, intoxication, therefore, before making a diagnosis, tomogram data is always assessed after analyzing the clinical situation and testing the cerebrospinal fluid. An MRI of the spinal cord is often required.

MRI: acute disseminated encephalomyelitis

• Acute disseminated encephalomyelitis. Multifocal lesions appear on tomograms 1.5-2 weeks after contact with the pathogen or vaccination. Other structures of the nervous system may also be involved in the process. Better visualization of lesions is provided by contrast. The size of the demyelinated areas is larger than in multiple sclerosis, and the disease is more often diagnosed at a young age.

MRI: Neuroborreliosis (tick-borne encephalitis)

• Lyme disease. Magnetic resonance scanning shows pinpoint lesions, a similar picture can be observed in autoimmune diseases. But for this nosology, a specific rash on the skin and a malaise resembling a cold and arthralgia are also typical. Tomograms show a hyperintense signal from the spinal cord and accumulation of paramagnetic in the region of the root zone of the VII pair of cranial nerves.

Sarcoidosis on MRI: yellow arrows indicate lesions of the membranes, cranial nerves, similar changes are present in the trunk

• Sarcoidosis of the brain. The diagnosis is difficult to establish only with magnetic scanning; sometimes final verification occurs after a biopsy. The picture on the tomograms resembles the changes characteristic of multiple sclerosis.

Negative dynamics on tomograms performed at monthly intervals for leukoencephalopathy

• Progressive multifocal leukoencephalopathy. The pathogenetic factor is infection with the Cunningham virus, which affects people with immunosuppression (severe dysfunction of the immune system). There is damage to the arcuate fibers of the white matter, with contrast there is no accumulation effect. Pathological foci are often localized on one side, sometimes symmetrical changes are visible.

Causes of dystrophy

The full picture of the appearance of dystrophic changes is not yet clear to researchers. But numerous observations have led to the conclusion that most cases of this pathology have a genetic predisposition. The action of provoking factors only accelerates the development of the process or enhances its manifestation.

Therefore, the reasons that cause focal changes in the brain substance of a dystrophic nature can be safely divided into genetic abnormalities and acquired ones. Although it should be noted that acquired causes are still a very conditional definition in this case, since they begin their destructive effect only if the patient is predisposed to the specified pathology.

Dystrophic changes in the brain on MRI

Cerebral angiography

When the blood supply is disrupted, oxygen and trophic starvation of cells (ischemia) develops. This leads to degenerative processes and is accompanied by dysfunction. The severity of the latter is variable, depending on whether blood is completely blocked or a partial influx remains. Dystrophic changes can be local or diffuse. Total brain damage is recorded in meningitis, encephalitis, focal changes are typical for cysts, small ischemic processes, and the formation of post-traumatic scars.

Clinical manifestations may include:

• headache;
• high blood pressure;
• the appearance of paresthesia (a feeling of numbness or tingling in the limbs), loss of sensitivity;
• deterioration of vision (up to blindness, which indicates damage to the optic nerve), memory, decreased intellectual abilities;
• insomnia;
• hyperkinesis (uncontrolled muscle contractions) and convulsions.

As the pathology progresses, paresis and paralysis are expected, so it is important to do an MRI of the brain vessels at the first symptoms of trouble. Single lesions can be detected in young men and women and do not always indicate pathology. The doctor’s tactics are dynamic observation and repeated magnetic scanning after 3-6 months, which will allow not to miss the development of any serious disease, for example, multiple sclerosis. Over the age of 60-65 years, lesions are found in almost all patients, which is explained by natural aging. These changes are irreversible, but the progression of the process can be slowed down with adequate treatment.

Provoking factors include:

• chronic alcohol and nicotine intoxication;
• stressful situations;
• irrational work and rest regime;
• obesity;
• low physical activity;
• persistent increase in blood pressure;
• diabetes;
• hypercholesterolemia.

The type of dystrophic disorders in the gray and white matter of the brain on MRI will depend on the nature of the pathological process.

Second stage

At the initial stage of damage to the human brain, signs of the disease practically do not appear. The patient can only complain about lack of strength and apathy. At this stage, sources of problems in blood vessels are just emerging and are difficult to distinguish.

A focal change in the substance of the brain of a dystrophic nature in the second stage is manifested by more serious symptoms: a person’s headache intensifies, the ability to perceive and process information decreases, ringing in the ears appears, coordination of movements is impaired, the character becomes more irritable and aggressive.

When the disease reaches the third stage of development, the brain pathology is considered irreversible. Gradually, the patient develops symptoms of dementia, paralysis and paresis rapidly develop, and the senses work with less and less efficiency.

Vascular changes in the brain on MRI

MRI: ischemic zone during stroke (highlighted with a red oval)

If cerebrovascular pathology is suspected, special attention is paid to the condition of the arteries during MRI of the brain. The study always involves the introduction of contrast, and it is called magnetic resonance angiography. In urgent situations in case of vascular accidents, CT is performed, since X-ray diagnostics takes less time and clearly demonstrates the area of ​​damage during hemorrhages, but after stabilization of health, magnetic resonance angiography is quite justified. The study shows atherosclerotic plaques, blood clots and aneurysms (protrusions), their localization, and wall deformation.

With an ischemic stroke, darkened and blurred areas of irregular shape are visible almost immediately on magnetic tomograms, appearing on a computer scan only at the end of the first day. The lesion is often unilateral. The outpouring of blood from a ruptured vessel gives an intense light color, but only in the first hour and a half from the moment of the disaster, and then becomes invisible on MRI, although it is clearly visualized using CT. As a consequence of a stroke, a fluid-filled pseudocyst is formed, and deformation of the nerve tissue appears. MRA is indispensable in the diagnosis of tumor angiogenesis. Increased vascularization of a pathological focus is always suspicious of a malignant neoplasm, which grows and feeds due to increased blood flow. If the vessels do not keep up with the growth of the tumor, areas of ischemia and necrosis appear.

Diet

Damage to certain areas of the brain is not uncommon. As mentioned above, in order to eliminate such a pathology, it is very important to take comprehensive measures. You will also need to adjust your diet, because what we eat directly determines how we feel.

It is very important to include foods rich in vitamins B, C and PP in your diet. It is also beneficial to eat foods rich in magnesium and potassium. If the patient has a disordered fat metabolism, then experts recommend eating foods that can break down fats. First of all, garlic and onions should be included here. Try to eat cereals daily, as they strengthen the walls of blood vessels very well. Also, eat seafood at least twice a week.

In the early stages of this disease, it is enough to reconsider your lifestyle and diet, choosing a more gentle regimen and diet. In the diet, it is advised to reduce the consumption of animal fats, and it is better to completely replace them with vegetable ones. You should eat fish and seafood instead of fatty meat, and reduce the amount of salt in your diet. Fresh vegetables and fruits will be of great benefit.

Normal magnetic resonance imaging of the brain

MRI of the brain, normal

The normal MRI of the brain is a relative concept, depending on the age, gender of the patient, changes in tomograms are necessarily compared with symptoms. The doctor evaluates the symmetry of the lobes, the size of the ventricles, blood vessels, the uniformity of their filling with a contrast agent, the absence of neoplasms, malformations, and much more. A computer program builds layer-by-layer images, after examination they are printed onto films and examined by placing them on a X-ray viewer. Next, fill out a conclusion form indicating the preliminary diagnosis. It is hardly possible to decipher an MRI of the brain on your own without special training: an inexperienced person, even if he sees a lesion, will not figure out what caused its appearance. All questions can be asked to the doctor who conducted the study. In unclear situations with ambiguous results, obtaining a second opinion is justified. Often patients, having read the words “neoplasm, tumor, NEO” in the conclusion, try to immediately find out the prospects of the disease from the radiologist, which fails. These questions can be answered by a neurosurgeon after receiving the biopsy results. Sometimes, to complete the picture, it is necessary to additionally do an MRI of the cervical spine.

How is the diagnosis made?

The diagnosis of “focal changes in the brain substance of a dystrophic nature” is quite difficult to establish. This requires identifying the signs of the pathologies listed above and excluding other somatic diseases and possible neuroses. By the way, people with diabetes and rheumatism are also at risk.

https://www.youtube.com/watch?v=IBPdOwK_kJI

The doctor must assess the patient’s condition, his neurological status, and also conduct the necessary examinations. The most accurate indications are provided by an MRI study, where lesions can be identified, as well as their size and location. Tomography makes it possible to determine changes in the density of brain tissue even in the initial stage of the disease. Correctly reading the MRI results is an important step in starting treatment for the problem described.