Capsules Stresam (Biocodex) - reviews

pharmachologic effect

Anxiolytic (tranquilizer).
Etifoxine hydrochloride belongs to benzoxazine derivatives. As an anxiolytic agent, etifoxine has an autonomous regulatory effect. In vitro and in vivo studies in rats and mice showed that the anxiolytic activity of etifoxine is due to the dual mechanism of its action (direct and indirect) on GABA-A receptors, which improves GABAergic impulse transmission.

When acting directly on the GABA-A receptor through allosteric modulation, etifoxine binds predominantly to the β2- or β3-receptor subunits; studies have shown that etifoxine binds to the GABA-A receptor at sites different from the binding site of benzodiazepines. The indirect effect is achieved by increasing the synthesis of neurosteroids (via activation of mitochondrial translocator protein), such as allopregnanolone, which is also a positive aplosteric modulator of the GABA-A receptor.

Consequences of drinking alcohol

There are no drugs without side effects, this is especially true if the dosage and course of treatment are not followed. This also applies to alcohol. After any substance, the body needs recovery, and this takes time.

Relieving stress and anxiety with two substances at once is a bad idea. Excessive alcohol consumption will worsen the condition that the medicine is treating.

Popular side effects:

• insomnia;
• increased adrenaline levels;
• heart rhythm problems;
• vasospasm;
• hypertension;
• loss of some liver functions;
• central nervous system dysfunction;
• noise in ears;
• intoxication;
• severe drowsiness;
• difficulties in movement and orientation in space;
• slow reaction.

When constantly mixing the drug with alcoholic beverages, not only the therapeutic effect is reduced, but a relapse of the disease occurs. Before starting treatment, it is important to give up the drink; this will reduce the risk for the patient and lead to a speedy recovery.

Pharmacokinetics

Suction

After oral administration, the drug is quickly absorbed from the gastrointestinal tract. The time to reach Cmax in the blood is 2-3 hours.

Distribution

Penetrates through the placental barrier.

Metabolism

Rapidly metabolized in the liver to the formation of several metabolites. One of the metabolites, diethylethifoxine, is active.

Removal

T1/2 of etifoxine is about 6 hours, T1/2 of the active metabolite is 20 hours. It is excreted mainly in the urine in the form of metabolites and in small quantities unchanged; also excreted in bile.

Use of the drug for alcoholism

Alcoholic drink in any quantity causes irreparable damage to the body. By inhibiting nerve fibers, ethanol impairs the functioning of the central nervous system. Due to the fact that a dependent person with alcoholism is diagnosed with dystrophy of peripheral nerves, the effect of inhibition of natural reactions is manifested.

That is why, after an alcoholic takes the drug, the resulting excitement is very difficult to calm down. Because of this, the patient copes poorly with stress and is constantly in an anxious, restless state.

The drug is prescribed for withdrawal symptoms, but with complete abstinence from alcohol. The dosage and duration of the course are determined by the doctor, taking into account all contraindications.

Side effects

Determination of the frequency of adverse events (AEs) observed while taking this drug: rare (≥1/10,000 and <1/1000), very rare (<1/10,000) in descending order of frequency.

From the nervous system:

rarely - slight drowsiness that appears in the first days of treatment and usually disappears on its own during treatment.

From the skin and subcutaneous tissue:

rarely - maculopapular rash, erythema multiforme, itching, facial swelling.

Allergic reactions:

very rarely - urticaria, Quincke's edema; frequency not established - anaphylactic shock, drug-induced hypersensitivity syndrome with eosinophilia, Stevens-Johnson syndrome, leukocytoclastic vasculitis.

From the liver and biliary tract:

frequency not established - hepatitis, cytolytic hepatitis.

From the genital organs and breast:

frequency not established - metrorrhagia in women taking oral contraceptives.

From the digestive system:

frequency not established - lymphocytic colitis.

STRESAM (capsules)

that... against this background, some kind of misunderstanding with relatives and ala... get:
dizziness... I lay there and was in a drunken delirium (I was just floating to work. It was impossible to work - work on the computer, no concentration), I turned to neurologists - they immediately — SVD — vascular-vegetative dystonia (pressure is normal)… ok… kokarnit (wonderful vitamins, of course, for the head and not only…) adaptol, vitamins B6, B9, B12 (I don’t remember the exact name), ok — I drink it — it’s easier. (at this stage the adaptol worked).

A month has passed - stress again... hello... dizziness here and there... again I’m running to the neurologists... give Emoxypine (for blood vessels) Noofen (a friend of Adaptol))) ok, let’s drink it... + headache (forehead usually) The neck is also involved - they prescribe Melbek injections. In short, I went to the sea... I swim - my neck doesn’t hurt - after all, swimming heals))) my head is spinning...

In the meantime, I go to neurologists, do an MRI - they find an indirect (this means that this does not exist - indirect signs) diagnosis in the head and immediately blame everything on him. Attributing it to me, but in reality it is not there. Immediately some injections with the brain of an animal are expensive - in general, it turned out to be a huge unnecessary waste of money.

I flew in... I went to see another neurologist (there were already 4 people) and he gave me needles, baths, a couch... massage... I did everything - I relaxed (as I now know) and what do you think, it became easier for me... sleeping with needles - oooo cool, that means eating Effect. I took a long course and also took phenibut - an excellent drug. What can I say, I’ll also write a review. Having gone through all this, where did my dizziness go?))) Thank God, I’ll tell you. But out of nowhere, the body’s dependence on natural changes, momentary storms, etc. appeared.

Two years later, I was advised to a specialist who specialized specifically in dizziness - ENT specialist Perminov, he is quite famous, as it turned out, in Minsk. Having come to him, it was clear to me that this man would tell me what was happening to me. After listening to my feelings and what was accompanied and when it began - in simple language he said - neurosis! (Thanks to all the rehabilitation procedures, I was cured) He prescribed me Strezam to consolidate the effect (but to be honest, I complained as if this was still happening to me - that was my investigation), but I no longer needed it at all. Having tried it, or rather taken it for almost a week, I did not feel any changes, carefully listening to myself. Therefore, I did not take it further. As for the side effects, I wanted to sleep.

The drug was prescribed for 2 months - this is the normal therapeutic dose, so to speak, 1 capsule 3 times a day.

Manufacturer of the drug - Biocodex, France

When I bought it, I was careful; we don’t take tranquilizers every day. I read that an allergic reaction is possible, I looked at the photographs - frightening for me - a person from an allergy does not have a white spot on the body.

The drug is available in these capsules.

The instructions say not to use the drug with alcohol.

So here it is. I took 1 tablet at night (taking 1 tablet at night to finish the blister), after a day I was about 100 ml. beer and Attention! I'm covered in hives all over my whole body, but it's not pronounced, but it's still noticeable. Here it is - an allergic reaction and when, date and time when alcohol appeared. Warning there are instructions no complaints, but a day has passed - 24 hours, and the drug is removed within 6 hours. There shouldn't be such a reaction anyway.

My advice is not to buy a lot of capsules at once, but try to see if the body rejects it. Maybe my review will help, if you have questions, please write, I didn’t write everything in my story, there was still a lot of interesting things and analyzes of all sorts of examinations.

I love medicine, I love helping others and myself!

special instructions

If skin or allergic reactions occur, as well as complications from the liver, the drug should be discontinued.

If you miss a dose of the drug, you should not double the dose the next time you take it.

The dose prescribed by the doctor should not be exceeded.

It is not recommended to take the drug while drinking alcoholic beverages.

Use in pediatrics

It is not recommended to use the drug in children and adolescents under 18 years of age.

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Impact on the ability to drive vehicles and operate machinery

Due to the risk of drowsiness, you should avoid driving vehicles and activities that require increased attention, such as operating various mechanisms.

Compatibility of Stresam and alcohol

? According to doctors, it is prohibited to take Stresam and alcoholic beverages together, as this can provoke an increase in the effect of both substances on the body.

When taking an antidepressant and alcohol, there are two scenarios:

1. At best, ethanol in the blood will block the effect of the drug. This is due to the fact that both substances load the liver, so it quickly passes the drug, which has not yet had time to act. The person’s condition worsens, fear and anxiety increase.
2. The active substance of the drug in combination with alcohol threatens to increase serotonin and hyperactivity of the serotonin system. This leads to overexcitement of a person, confusion, trembling in the body and an increase in temperature. Often the combination threatens to depress the respiratory system, causing asphyxia and death.

The effects manifest themselves differently for each person; in rare cases, adverse reactions do not occur at all. If you feel unwell or noticeably worsen the patient’s condition, you should immediately contact your doctor to avoid serious complications from treatment.

Release form, composition and packaging

Capsules

gelatin, size No. 2, smooth, shiny, with a white body and a blue lid; the contents of the capsules are white or white powder with a slight yellowish tint.

Excipients:

lactose monohydrate - 119 mg, talc - 15 mg, microcrystalline cellulose - 10 mg, colloidal anhydrous silicon dioxide - 3 mg, magnesium stearate - 3 mg.

Shell composition:

titanium dioxide, gelatin, indigo carmine.

12 pcs. - blisters (2) - cardboard packs. 20 pcs. - blisters (3) - cardboard packs.

When can you take the drug, after how long

The drug is allowed to be taken only after the last signs of a hangover have ceased. Based on the elimination time of the drug and alcohol, we can say that a man can take the medicine only after 14 hours, but for women - 20 hours after the last dose of alcohol.

The time depends on the amount of drink drunk, its strength, weight and age of the drinker. You also need to take into account related factors - the emotional and physical state of the person, ambient temperature, smoking while drinking the drink.

For example, if there are problems with the exocrine gland and the paired organ, the body devotes all its efforts to cleansing itself of toxins, which leads to a prolongation of the hangover. The doctor will tell you exactly how long you can drink.

Pharmacological properties of the drug Stresam

In therapeutic doses, etifoxine hydrochloride has an anxiolytic effect. Etifoxine does not affect the speed of psychomotor reactions and can be used as a daytime tranquilizer. Etifoxine hydrochloride is well absorbed from the gastrointestinal tract and is quickly metabolized in the body. The maximum concentration of etifoxine hydrochloride and its active metabolite (D3417) in the blood is achieved 1–2 hours after administration. The initial level of etifoxine hydrochloride and its active metabolite in the blood gradually decreases over the first 2 hours and 20–30 hours, respectively. The half-life from blood plasma is 20–30 hours. Ethoxyfin and its main metabolite are excreted mainly in the urine.