Pramiracetam: effects, reviews, instructions for use.

Pramiracetam is a drug that can improve memory and overall cognition. Its unique properties make it a potentially powerful brain performance optimizer on its own or in a nootropic stack.

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Benefits and Effects of Pramiracetam

Pramiracetam is a true nootropic created specifically to improve cognition. Its benefits and effects include the following:

Improved memory

Pramiracetam is a proven memory enhancer that has been extensively tested for several decades. It has proven effective in both animal studies and clinical trials on young people with cognitive impairment due to brain injury.

Pramiracetam improves memory by stimulating the hippocampus, the part of the brain responsible for creating new memories. It is also effective in reducing forgetfulness. This dual action makes Pramiracetam a very effective memory enhancer. User reviews also report significant improvements in memory recall speed, which is supported by animal studies.

Increased attention and improved learning ability

Pramiracetam's reputation as a general cognitive enhancer has made it a popular choice among students.

Pramiracetam contributes to mechanisms underlying learning and memory by increasing neuronal nitric oxide synthase (NOS) activity in the hippocampus. NOS activity is associated with neural development and brain plasticity, which are critical for all aspects of cognition.

Pramiracetam is also known to increase the absorption of choline, thereby indirectly stimulating the production of acetylcholine. It is an important neurotransmitter that is closely associated with learning and cognition.

Dementia treatment

Open-label studies in patients with primary degenerative dementia show that pramiracetam is effective in reversing amnesia, significantly improving memory and reducing forgetfulness.

In other studies that measured the effects of pramiracetam and other racetam class nootropics in patients with mild to moderate dementia, results included cognitive and memory improvements. These results are believed to be due, at least in part, to the nootropics' potentiation of existing neurotransmitters.

Pramiracetam is commonly prescribed in Europe to treat dementia and other cognitive problems; associated with Alzheimer's disease and other neurological disorders.

"Social Freedom"

According to user reviews, it is known that pramiracetam makes them more creative in communication and socially free. This may be due, at least in part, to the supposed emotional blunting of pramiracetam. This effect may reduce social anxiety and, in turn, increase social freedom.

Neuroprotective capabilities

Pramiracetam is known to have significant neuroprotective effects that can improve cognitive function in people who have suffered traumatic brain injury.

It also has a pronounced neuroprotective effect when used during coronary artery bypass surgery, as well as in the treatment of cognitive disorders of cerebrovascular origin.

Subjective sensations from taking the drug

Of the subjective sensations of taking pramiracetam, the most significant are acceleration of thinking without pronounced psychostimulation, improvement of memory up to photographic with a course of taking it for two months, improvement of mental status, self-confidence, increase in motivation and communication skills, general increase in performance, decrease in mental fatigue, increase in ability concentrate on a specific task for hours. There is also an improvement in visual, tactile and auditory perception of information, a change in worldview, habits and other things. In general, after a course of taking Pramiracetam, many people note the extremely positive impact of a course of Pramiracetam on their personality, a change in character and worldview, and even getting rid of mental problems that prevented them from living. This is not science fiction in any way; these effects are precisely explained by a noticeable increase in the number of neurons in the hippocampus, strengthening the connection between them and the rest of the brain. This process can be characterized as an extremely powerful enhancement of the adaptive capabilities of the brain to adapt to new environmental conditions.

How pramiracetam works

Like most nootropics, pramiracetam affects the release of neurotransmitters. Brain chemicals that transmit signals from one nerve cell to another. But pramiracetam does this in an indirect way, different from the normal action of racetam supplements, and also stimulates the brain in other ways.

Most racetams work by directly stimulating neurotransmitters, thereby increasing their production. But pramiracetam does not directly lead to changes in neurochemical levels. Its main direct effect is to significantly increase choline uptake in the hippocampus.

Choline is a precursor to acetylcholine. A neurotransmitter deeply involved in all cognitive processes, including learning speed, memory and concentration.

By stimulating the uptake of choline, pramiracetam indirectly modulates the release of acetylcholine and stimulates increased activity in the hippocampus. Because this part of the brain is important for memory function, the overall stimulation that pramiracetam provides can improve both the formation of new memories and the retention of referent or long-term memories. Increased activity in the hippocampus also increases cerebral blood flow, which increases attention and improves overall cognitive performance.

Pramiracetam may have other mechanisms of action. Researchers have hypothesized that in addition to its effects on the brain, pramiracetam acts in peripheral sites outside the brain that are dependent on the adrenal glands.

Animal studies suggest that pramiracetam may also increase or restore the fluidity of brain membranes, which facilitates cell signaling.

Unlike many other racetam class nootropics, pramiracetam does not appear to actively alter wakefulness or emotional states. This may be explained by the limited effect of pramiracetam on the production and release of neurotransmitters that have the greatest impact on mood and anxiety levels, such as serotonin, GABA and dopamine.

Pramiracetam is fat soluble, not water soluble, which means it is absorbed into the bloodstream through fatty acids. It reaches peak concentrations and maximum bioavailability relatively quickly, usually within 30 minutes, and has a moderately long half-life of 4.5-6.5 hours.

Result:

1. Pramiracetam is a powerful nootropic from the racetam group.
2. Works through increased production of acetylcholine.
3. Effects: memory, easy learning, improved mood.
4. Course – 2 months. 1-1.5 grams/day, divided into 2 doses.
5. Be sure to take an additional source of choline or choline as a supplement, otherwise your head may hurt and pramiracetam will not work as well. Can be combined with piracetam or noopept.

That's all for today! Good luck and see you again)

Instructions for use, dosage of pramiracetam

Existing human studies have used a total daily dose of 1200 mg of pramiracetam, divided into two or three doses per day.

This dosage is optimal, effective and well tolerated. It can be a good guide in determining dosage based on personal needs.

It is always advisable to start with the lowest possible effective dose and adjust the amount if necessary.

The fact that pramiracetam is fat-soluble and not water-soluble means that mixing the powder with water or any non-greasy liquid is difficult. Instead of dissolving, it will simply float on the surface. Some users report diluting their dose of pramiracetam powder with a small amount of oil. It may also improve absorption and bioavailability.

Many people prefer to take pramiracetam in capsule form because of its taste.

Features of taking the drug

It is extremely important to use pramiracetam in conjunction with choline sources: choline bitartrate, DMAE, choline alfoscerate (Alpha GPC), lecithin. Since due to the extremely strong activation of choline absorption by neurons, with a lack of choline in the bloodstream, neurons have to activate the enzyme phospholipase A, which destroys membrane phospholipids, in order to extract choline from phosphatidylcholine, and the consequence of this reaction, in addition to the destruction of membranes, is the formation of prostaglandins, which leads to a headache.

Combining Pramiracetam with Other Supplements

Pramiracetam works well on its own. But one of its most interesting aspects is that it is a powerful potentiator for other nootropics, increasing their effectiveness.

It is a particularly effective potentiator for other racetams, making it a natural addition to most nootropic stacks.

Adding choline to a pramiracetam stack may have several benefits. Not only can it enhance the effects of pramiracetam, but it can also prevent headaches, which is the most common side effect.

Since Pramiracetam has such powerful effects, it is advisable to use it on its own for a trial period before combining it with other nootropics.

Stack of Pramiracetam and Oxiracetam

Combining pramiracetam with an energy booster such as adrafinil or oxiracetam can enhance mental alertness and last longer.

1 per day

• Pramiracetam 300 mg
• 750 mg oxiracetam
• 300 mg CDP choline

Pramiracetam and Aniracetam

Combining pramiracetam with a powerful anti-anxiety drug like aniracetam can give users increased alertness, improving mood and reducing feelings of mental stress and restlessness. Reviews report that this stack promotes fluent communication and improves their public speaking ability.

1 per day

• Pramiracetam 300 mg
• 750 mg aniracetam
• 300 mg CDP choline

How can I help you

Chicken or quail eggs (minimum 2 chicken eggs per day) will be your best friends throughout the course of treatment. You really need a lot of choline, and pramiracetam works with it. If there is not enough choline in the system, your head will hurt.

A course with piracetam or noopept would be interesting. Don’t overexert your liver/kidneys, eat less fast food, less alcohol, more oatmeal and vegetables.

Side effects of piracetam

Pramiracetam is generally well tolerated even in high doses, and very few side effects have been reported.

There are rare reports of minor and transient side effects. Including headache, gastrointestinal distress and feelings of nervousness or agitation.

In many cases, side effects are associated with high dosage and can be avoided by reducing the amount.

Choline depletion headache is a common side effect of racetams and can be prevented by taking pramiracetam in combination with supplemental choline.

Pramiracetam is not addictive and no significant side effects have been reported with long-term use. In fact, there is evidence that this supplement may even promote brain health and restore aging brain function to some extent.

Release form

Pramiracetam is produced in tablet form and is called Pramistar, and also in the form of packages of 10, 25, 50, 75, 100 grams. A blister contains 10 or 20 elongated tablets in a cardboard package. The main component is pramiracetam 600 mg and 200 mg of additional substances:

• MCC is a natural raw material and has properties similar to fiber in vegetables and fruits. The use of microcrystalline cellulose makes the tablets durable and homogeneous, helping to gradually release the main substance;
• Crospovidone will accelerate the process of disintegration and absorption of the drug, improve the release of useful substances. It is a fast-acting agent to facilitate dissolution in the gastrointestinal system;
• Emulsifier calcium stearate is a synthetic compound used to create a stable solid form of the drug and vitamins;
• The food additive silicon anhydrite is used as an effective enterosorbent that removes toxic substances from the body;
• Macrogol is a synthetic non-absorbable component with a pronounced osmotic effect. Titanium dioxide is approved in the food and pharmaceutical industries as a dye and to provide a whitening effect;
• Hydroxypropylcellulose and hydroxypropylmethylcellulose are used as food additives with stabilizing and emulsifying properties.

Final Thoughts

Pramiracetam is a unique and powerful nootropic. Which has been shown to improve memory, improve overall cognition, and act as a neuroprotector.

Pramiracetam is prescribed in Europe for the treatment of dementia. In the US and Canada, it is most often used off-label as a nootropic.

Pros of pramiracetam include the fact that it is safe and generally well tolerated, with few side effects. It is powerful, fast-acting and relatively long-lasting. Effective on its own and with other compounds in nootropic stacks. Users typically report that it helps them study effectively and remember well, along with increased focus. Many users also say it increases their sense of social freedom.

The disadvantages of Pramiracetam include taste and price, which is usually higher than other racetam-type nootropics.

Overall, pramiracetam is considered a safe and effective nootropic. If you're interested in improving your memory, learning speed, and overall mental acuity, it might be worth considering.

The best racetam, is there one?

The three most popular racetams are known: aniracetam, oxiracetam and pramiracetam. “Which substance is the best?” is a common question from many people on various forums.

All of these remedies have similarities, but different side effects, which is confusing. Considering that they all have completely unique chemical components, this means that each substance will act on the brain differently.

Each of this chain has excellent nootropic effects. For example, the ability to develop memory and acquire new skills. However, there are also nuances in the difference, as well as in the consequences after use.

Consumers' point of view

Reviews of Pramiracetam from most patients who were prescribed the medicine are mixed. Patients noted that the drug improves memory and stimulates the mental process. Negative reviews are associated with drowsiness and disgust that occur on days of use. But patients noted improved sleep. The drug is effective in the treatment of cranial and brain injuries and restoration of mental functioning in the elderly.

The negative aspects of the drug include its price and inaccessibility. In Ukraine, Pramistar is sold in a regular pharmacy, and its price is 300 hryvnia. In Russia (Moscow, St. Petersburg) you can only buy it in an online pharmacy, the price depends on the weight and ranges from 1000 to 7000 rubles.

It does not cause side effects, but there is a minus, there is no immediate effect, the effect is cumulative.

Irina, 35 years old

The drug is effective, but there are many analogues that are cheaper.

Alexander, 42 years old

Pramiracetam is a strong psychostimulant and is contraindicated for people with unstable mental health. Reviews from medical specialists boil down to the fact that the effect of Pramiracetam has not been studied. The drug is a powerful psychotropic drug that must be prescribed as prescribed by a doctor.

Svetlana, 38 years old, doctor