Trittico is a drug from the group of antidepressants that has a mixed effect on serotonin metabolism. It helps fight mild to moderate depression, but has an adverse effect on the body when taken together with alcohol.
Side effects of Trazodone
From the nervous system and sensory organs:
fatigue, weakness, headache, dizziness, insomnia, drowsiness, agitation, psychosis, hypomania, hallucinations, tremor, muscle twitching, grand mal seizures,
aphasia
, ataxia, akathisia, dyskinesia, paresthesia, confusion, syncope, blurred vision, diplopia.
From the cardiovascular system and blood (hematopoiesis, hemostasis):
arterial hypotension, incl. orthostatic; atrial fibrillation, arrhythmias (including tachy- and bradycardia, ectopic ventricular rhythms), congestive heart failure, leukocytosis or leukopenia, neutropenia (usually minor), hemolytic anemia, methemoglobinemia.
From the gastrointestinal tract:
increased appetite, dryness and unpleasant taste in the mouth, hypersalivation, caries, diseases of the periodontal tissues, oral candidiasis, nausea, vomiting, flatulence, diarrhea, constipation, cholestasis, increased levels of bilirubin and amylase in the blood plasma, jaundice.
From the genitourinary system:
urinary retention, increased frequency of urination, hematuria, premature menstruation, hirsutism, increased libido, priapism, impotence, retrograde ejaculation.
Allergic reactions:
skin rash, urticaria.
Other:
myalgia, chest pain, alopecia, psoriasis, edema.
About the drug
Trazodone is marketed under the brand name Trittico. The action is based on an increase in serotonin in the brain centers that are responsible for a person’s emotional state.
The peculiarity of the drug is its rapid action. After just a week of taking the product, you can feel its effect. The antidepressant has a muscle relaxant, calming and sedative effect.
Distinctive features of Trittiko:
- does not provoke weight gain;
- relieves fear and anxiety;
- normalizes sleep;
- relieves irritability;
- reduces the severity of headaches;
- relieves limb tremors;
- works well against nervous urge to urinate.
"Trittiko" does not affect human hormonal levels and metabolic rate. The drug penetrates histohematic barriers and can enter bile, saliva, and breast milk.
Interaction
Unlike typical antidepressants, it does not reduce the depressive effects of reserpine, weakens the central effect of amphetamine and the peripheral effect of norepinephrine. Potentiates the effect of CNS depressants (including barbiturates, tricyclic antidepressants, antihistamines, clonidine, alcohol), anticholinergics and muscle relaxants. When taken simultaneously with antihypertensive drugs, the risk of orthostatic hypotension increases. Weakens the effect of psychostimulants. Increases plasma concentrations of digoxin and phenytoin. Should not be used simultaneously with MAO inhibitors.
Interaction with ritonavir
The effect of short-term administration of ritonavir (200 mg twice daily for 2 days) on the pharmacokinetics of a single dose of trazodone (50 mg) was studied in 10 healthy subjects. It was shown that Cmax of trazodone increased by 34%, AUC by 2.4 times, T1/2 by 2.2 times, clearance decreased by 52%. Adverse effects including nausea, hypotension, and syncope have been observed when ritonavir and trazodone were used together. If ritonavir and trazodone are used concomitantly, a dose reduction of trazodone may be necessary.
Interaction with CYP3A4 isoenzyme inhibitors
In vitro studies of the metabolism of trazodone indicate the possibility of its interaction with inhibitors of the cytochrome P450 isoenzyme CYP3A4, such as ketoconazole, ritonavir, indinavir sulfate and fluoxetine. Inhibitors of CYP3A4 may lead to significant increases in plasma concentrations of trazodone, thereby increasing the likelihood of adverse events. Therefore, when used in combination with potent CYP3A4 inhibitors, the dose of trazodone should be reduced.
Interaction with carbamazepine
After co-administration of the CYP3A4 inducer carbamazepine (at a dose of 400 mg / day) with trazodone (100-300 mg daily), carbamazepine reduced the plasma concentrations of trazodone and m-chlorophenylpiperazine (the active metabolite) by 60 and 76%, respectively. Patients receiving trazodone and carbamazepine concomitantly should be closely monitored.
Interaction with warfarin
There are reports of changes (increase or decrease) in PT with simultaneous use of warfarin and trazodone.
What happens if you take it together?
Taking Trittico and alcoholic beverages together can lead to the following adverse symptoms:
- allergy;
- decreased hemoglobin concentration;
- decreased leukocyte levels;
- failure in the synthesis of vasopressin;
- suicidal thoughts and actions;
- loss of appetite;
- nightmares;
- hallucinations;
- increased aggressiveness;
- convulsive syndrome;
- memory impairment;
- failure in the ECG pattern;
- disruption of the heart;
- dyspnea;
- blood pressure surges;
- disturbances in liver function;
- urinary disorders;
- muscle pain;
- exacerbation of the current disease.
In severe cases, death is possible.
Precautions for the substance Trazodone
During treatment, a general blood test should be performed regularly (for timely detection of leuko- and neutropenia); ECG monitoring is desirable in patients with cardiovascular diseases. Careful monitoring of patients with suicidal tendencies is required, especially in the first weeks of treatment. Treatment is immediately stopped with the development of priapism, severe neutro- and leukopenia; in other cases, drug withdrawal should be carried out gradually. During treatment you should avoid drinking alcohol.
Use with caution during work for vehicle drivers and people whose activities involve increased concentration.
SSRI antidepressants and alcohol: consequences
Serotonin is a signaling substance. Brain cells exchange serotonin molecules to transmit information. If a person is depressed, then he has an imbalance of serotonin.
SSRI antidepressants stabilize the patient's mood, easing the course of depression.
SSRI drugs contain the following active ingredients:
- Fluoxetine;
- Sertraline;
- Paroxetine;
- Citalopram;
- Escitalopram;
- Fluvoxamine;
- Venlafaxine;
- Duloxetine.
Alcoholic drinks should not be combined with selective serotonin reuptake inhibitors, as they increase the side effects of taking antidepressant medications. Also, such combinations can cause depressive psychosis, sexual disorders, and the appearance of hallucinations.
Difficult blood clotting, a sudden decrease or increase in blood pressure, and arrhythmia are possible. Secretory functions may deteriorate.
Complex autonomic disorders may appear.
Is it easy to quit drinking without coding?
It is very difficult to refuse to use ethyl alcohol without passing the coding. For most patients, this task turns out to be overwhelming. It's all about disruption of metabolic processes.
The fact is that, coming from outside, ethyl alcohol becomes a participant in important metabolic reactions. In this case, the body’s own production of ethanol is blocked. If a person stops drinking, his body seems to resist. Then unpleasant symptoms arise, pushing you to another feast. They are comparable to drug withdrawal, but not as painful.
Should you be afraid of coding?
There's nothing scary about coding. You just need to consult an experienced doctor to carry it out. Today, medication and psychotherapeutic programs are used to reduce cravings for drinking. They have proven themselves to be safe and effective.
The only thing is that the drinker needs to be determined to recover and under no circumstances drink alcohol after coding. Then everything will be fine with his health.
a brief description of
This is a popular antidepressant with the active ingredient trazodone. The drug increases the production of serotonin in the brain. Due to the improvement of serotonin metabolism, depression and increased anxiety are eliminated.
The tablets are not addictive and do not affect weight. In addition to depression, the drug is prescribed to treat the following conditions:
- decreased libido, impotence;
- hypogenic apathy;
- cerebral atherosclerosis;
- apathy with prolonged pain syndrome;
- dementia due to aging processes;
- chronic dependence on alcoholic beverages;
- phobias;
- migraines, bulimia;
- progressive Alzheimer's disease;
- anxiety syndrome;
- constant craving for benzodiazepine.
You should absolutely not take the medicine under the following restrictions:
- Pregnancy, breastfeeding.
- Hypertension, tachycardia.
- Hypersensitivity or individual intolerance to the components of the drug.
- Kidney, liver failure.
- Under the age of six.
- Priapisms.
- Extrasystoles of the stomach.
- Initial recovery after myocardial infarction.
It is also contraindicated for use by minors, since the teenage body is often subject to suicidal thoughts, so this antidepressant can develop aggression and worsen the psycho-emotional state. Due to the presence of sucrose in the composition, the medicine is prohibited for patients with fructose intolerance.
https://myweak.ru/alkogolizm/lekarstva/trittiko-sovmestimost.html
How to stop drinking without coding
There are no secret recipes. All that is required for healing is to completely stop drinking alcohol. This must be done overnight, and not “draw out the pleasure.”
Some patients talk about a gradual withdrawal scheme. It involves a gradual reduction in the doses of alcohol used. Such a program has nothing to do with effective therapy.
Alcohol addicts need to give up drinking completely. Moreover, after recovery you will not be able to drink strong drinks for the rest of your life. Alcoholism is a serious chronic disease. Its relapses occur very often. Therefore, the “tie” must be final and irrevocable.
Content:
- Briefly about Olanzapine
- Side effects of the drug
- Intentional combination of products
- Olanzapine and alcohol alter brain activity
Olanzapine is a medicine used to treat various mental disorders.
Usually they drink it for a long time - up to several years. It is not surprising that some patients have questions about the compatibility of Olanzapine and alcohol. The official instructions indicate that these compounds cannot be used at the same time. Below we will explain what this limitation is associated with.
Is it possible to drink alcohol with herbal antidepressants?
Mild herbal antidepressant drugs are known to have a mild calming effect. If a specialist has prescribed a person to take a course with such drugs, then drinking alcoholic beverages in this situation is not prohibited. However, you need to drink it in small doses to avoid a hangover.
The minimum break between drinking alcohol should be 7 days.
Thus, you must carefully read the instructions for the medications prescribed by your doctor. If “Antidepressant” is indicated in the “Pharmacological group” section, this means that drinking alcohol is prohibited during the period.
