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Atherosclerotic plaques – the morphological “carriers” of atherosclerosis – go through a number of successive stages in their development (a - d). a – In the early stages of formation, sclerotic plaques contain a large amount of lipids and have a thin connective tissue capsule. They are called vulnerable, or yellow plaques. b – The thin connective tissue membrane of yellow plaques can be damaged both due to the influence of hemodynamic factors (pressure changes in the vessel, narrowing and stretching of the wall), and as a result of the fact that the cells of the immune system contained near the membrane produce proteins that can destroy the protective cell matrix c – Erosion, or rupture, of the connective tissue capsule of the yellow plaque occurs at its edge. Violation of the integrity of the fibrous capsule leads to contact of the fats contained in the plaque with platelets and, accordingly, to the immediate formation of a blood clot. d – At later stages of development, fibrous plaques have a strong connective tissue capsule and contain relatively few lipids and a lot of fibrous tissue. The possibility of rupture of such a dense fibrous capsule is not excluded, but is much less likely than that of a yellow plaque
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